Recent publications by Dr. Carole Samango-Sprouse

The Neurodevelopmental Outcome in a Large Prospective Population of Infants and Preschoolers with 47, XXY (Klinefelter Syndrome) submitted to Prenatal Diagnosis 4/15/16

Samango-Sprouse, Carole ; Lawson, P; Sprouse, C; Stapleton, E; Sadeghin, T; Gropman, A.. Expanding the Phenotypic Profile of Kleefstra Syndrome: A Female with Normal Intelligence and Childhood Apraxia of Speech. Am J Med Genet Part A. Under review

Expanding the Phenotypic Profile of Kleefstra Syndrome: a Female with Low-Average Intelligence and Childhood Apraxia of Speech. American Journal of Medical Genetics. in press

Samango-Sprouse, C;  Hall, MP;  Kırkızlar, E; Curnow, K; Demko, Z; Lawson, P; Gross,S; Gropman, A. Incidence of X and Y Chromosomal Variations in a Large Child Bearing Population. under review November, 2015

Keen, C, Stapleton, E; Sadeghin, T;  Powell, S; and Samango-Sprouse, C.. A Cohort Study of Boys with 47, XXY: Mathematic Capabilities and the Impact of Familial Learning Disabilities (FLD) under review, Journal of Clinical Genetics, October, 2015

Samango-Sprouse C, Keen C, Mitchell F, Sadeghin T, Gropman A. 2015. Neurodevelopmental variability in three young girls with a rare chromosomal disorder, 48, XXXX. Am J Med Genet Part A 9999A:1–9.

Samango-Sprouse, C. A., Stapleton, E., Mitchell, F. L., Sadeghin, T., Donahue, T. P., Gropman, A. L. Expanding the Phenotypic Profile of Boys with XXY – Is it all about the X?, Am J Med Genet Part A. 2014 Jun;164(6):1464-9. doi: 10.1002/ajmg.a.36483. Epub 2014 Apr 8.

Samango-Sprouse, C. A., Stapleton, E., Aliabadi, F., Graw, R., Vickers, R., Haskell, K., Sadeghin, T., Jameson, R., Parmele, C. L., Gropman, A. L. Early Identification of Infants and Toddlers At Risk for Autism Spectrum Disorder (ASD) and Developmental Language Disorder (DLD), Autism, 1362361314521329, first published on February 18, 2014

Samango-Sprouse C, Banjevic M, Ryan A, Sigurjonsson S, Zimmermann B, Hill M, Hall MP, Westemeyer M, Saucier J, Demko Z, Rabinowitz M. SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy. Prenat Diagn. 2013 Jul;33(7):643-9. doi: 10.1002/pd.4159. Epub 2013 Jun 20.

Samango-Sprouse CA, Stapleton E, Sadeghin T, Gropman AL. 2013. Is it all the X: Familial learning dysfunction and the impact of behavioral aspects of the phenotypic presentation of XXY? Am J Med Genet Part C Semin Med Genet 163C:27–34.

Samango-Sprouse CA, Gropman AL. 2013. Introduction: Past, present, and future care of individuals with XXY. Am J Med Genet Part C Semin Med Genet 163C:1–2

Sprouse C, Tosi L, Stapleton E, Gropman AL, Mitchell FL, Peret R, Sadeghin T, Haskell K, Samango-Sprouse CA. 2013. Musculoskeletal anomalies in a large cohort of boys with 49, XXXXY. Am J Med Genet Part C Semin Med Genet 163C:44–49.

Gropman A, Samango-Sprouse CA. 2013. Neurocognitive variance and neurological underpinnings of the X and Y chromosomal variations. Am J Med Genet Part C 163C:35–43.

Simpson, J.L., & Samango-Sprouse, C. (2013, February). Prenatal diagnosis and 47, XXY. American Journal of Medical Genetics Part C: Seminars in Medical Genetics (Vol. 163, No. 1, pp. 64-70). Wiley Subscription Services, Inc., A Wiley Company.

Samango-Sprouse, CA; Sadeghin, T; Mitchell, FL; Dixon, T; Stapleton, E; Kingery, M; and Gropman, AG. Positive Effects of Short Course Androgen Therapy on the Neurodevelopmental Outcome In Boys with 47, XXY Syndrome at 36 and 72 Months of Age. Am J Med Genet Part A DOI: 10.1002/ajmg.a.35769. October, 2012

Samango-Sprouse CA, Stapleton EJ, Mitchell FL, Sadeghin T, Gropman AL. 2012. Expanding the phenotypic profile of boys with XXY - is it all about the X? Oral Abstracts. J Intellect Disabil Res 56:927.

Rebecca E. Rosenberg, J. Kiely Law, Connie Anderson, Carole Samango-Sprouse and Paul A. Law. Survey of Vaccine Beliefs and Practices Among Families Affected by Autism Spectrum Disorders. CLIN PEDIATR published online 2 March 2012. http://cpj.sagepub.com/content/early/2012/02/22/0009922812438435.citation

Samango-Sprouse, CA . Explaining the phenotype of Trisomy X is available on the National Organization for Rare Disorders (NORD) website

Samango-Sprouse, CA. Sex Chromosome Disorders:  A Very Common but Rarely Diagnosed Disorder appeared as a Special Feature May/June 2011 in the online NeuroDevelopmental  Treatment Association (NDTA) website.

Samango-Sprouse, CA;  Gropman, A;  Sadeghin, T;  Kingery, M; Lutz-Armstrong, M;  Rogol, A. Early Effects of Short Course Androgen Therapy on Children with 49, XXXXY Syndrome on Neurodevelopmental Profile. Acta Pædiatrica May 2011.

Samango-Sprouse, CA . Expansion of the phenotypic profile of the young child with XXY. Pediatr Endocrinol Rev 2010 Dec; 8 Suppl 1: 160-8

Gropman, Andrea, Rogol, A., Fennoy, I., Sadeghin, T., Sinn, S., Jameson, R., Mitchell F., Clabaugh, J., Lutz-Armstrong, M., and Samango-Sprouse, C.A. Clinical Variability and Novel Neurodevelopmental Findings in 49, XXXXY. American Journal of Medical Genetics. Vol. 152A, No. 6.  June 2010.

Look at the child's learning style, neurocognitive ability
​and developmental differences.
Evaluate neurodevelopmental performance.
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Media Coverage

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  • The Washington Post  "Mother labored to find reason for son's developmental delays", Auguat 24, 2010 By Sandra G. Boodman. PDF

  • Voice of America News "Robots Help Children with Disabilities," December 8, 2009, by Julie Taboh. (The link connects to an article and video.) 
  • Time Magazine "Top 10 Medical Breakthroughs of 2009: New Research on Autism," December 8, 2009, by Alice Park. (In addition to leading The Focus Foundation, Dr. Samango-Sprouse serves on the steering committee of the Autism Genetic Resource Exchange, the organization featured in the Top 10 as well as in the article "Autism Linked to Genes That Govern How the Brain is Wired," April 28, 2009, by Claudia Wallis. Dr. Samango-Sprouse was involved in the noted AGRE research from its inception, and she provided her clinical expertise in Autism and other neurogenetic conditions to ensure the optimal usage and success for families whose children who have Autism and/or related disorders.) 

  • The New Yorker "Robots That Care: Advances in technological therapy," November 2, 2009, by Jerome Groopman. (Dr. Samango-Sprouse appears on pages 4 and 5 of this PDF download.) 
  • YouTube "CosmoBot, Summer 2009" (in English), and "CosmoBot, Spring 2009" (in Spanish) 

  • The Capital Annapolis.com Video "CosmoBot: Dr. Carole Samango-Sprouse explains the benefits of using robots such as CosmoBot with children who have sex chromosome disorders," August 6, 2009, video by Daniel Kohler 
  • The Capital(Annapolis, Maryland) "Robotherapy: Crofton specialist uses robot to help children with developmental disorders," August 6, 2009, by Theresa Winslow 

  • The Washington Post "I'm Here to Make You Feel Better: Robots can already perform surgery and track your meds. Now, new models aim to provide therapy and support," March 10, 2009, by Anita Slomski. (This article also appeared in the Winter 2009 issue of Proto, a magazine published by Massachusetts General Hospital.)
  • The Washington Post Video "Playing to Improve Speech Skills." March 9, 2009. In this 1-minute, 41-second Dr. Carole Samango-Sprouse, founder of The Focus Foundation, and a six-year-old client use Play to Learn software during a therapy session. The software, along with a 16-inch tall robot named CosmoBot, helps improve attention span and motor and literary skills in children with developmental issues. 

  • The Quad-City Times "Davenport boy is beating the odds," October 2, 2008, by Deirdre Cox Baker (Davenport, Iowa) 
  • The Capital (Annapolis, Maryland). "No one understands how capable they are: Local doctor devotes career to helping children with sex chromosome disorders," July 24, 2008, by Theresa Winslow

  • Psychology Today "Why Danny Can't Read: One in 500 male babies is born with a second X chromosome, a condition known as Klinefelter syndrome. The vast majority of these boys develop language-related learning disabilities and dyslexia," March 1, 2003, by Willow Lawson